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Bioorganic & medicinal chemistry letters

Wake promoting agents: search for next generation modafinil, lessons learned: part III.


PMID 22546675

Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

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