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Molecules (Basel, Switzerland)

A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones.


PMID 22547316

Abstract

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.