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Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

Effects of testosterone propionate on oxidative stress and the expression of spleen cytokine genes in endosulfan-treated mice.


PMID 22591281

Abstract

The purpose of this research was to investigate the effects of testosterone propionate on oxidative stress and cytokine gene expression in endosulfan-treated mice. The levels of endosulfan and testosterone propionate were 0 and 0 mg x kg-1 x d(-1) (control group), 0.8 and 0 mg x kg-1 x d(-1) (endosulfan-treated group), and 0.8 and 10 mg x kg(-1) x d(-1) (experimental group), respectively. The results showed that total antioxidation capability (T-AOC) in the endosulfan-treated group was reduced significantly when compared with the control group, whereas the levels of malondialdehyde (MDA) and hydroxyl free radicals increased when compared with the control group. T-AOC levels in the experimental group were higher than that of the endosulfan-treated group, and the levels of MDA and hydroxyl free radicals decreased when compared with the endosulfan-treated group. The messenger RNA (mRNA) levels of interleukin (IL)-2 and IL-6 in the endosulfan-treated group were significantly higher than that of the control group. The mRNA levels of IL-6 in the experimental group were lower than that of the endosulfan-treated group, whereas the mRNA levels of IL-2 and interferon-γ had no significant difference between the 2 groups. The results suggest that testosterone propionate alleviates oxidative stress induced by endosulfan and at least partially reverses the changes of cytokine gene expression in mice. It is possible that androgens affect cytokine expression by alleviating oxidative stress induced by endosulfan.

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T0300000
Testosterone propionate, European Pharmacopoeia (EP) Reference Standard
C22H32O3