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Organic letters

Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination.


PMID 22670815

Abstract

An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp(2))-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

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