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Physical review letters

Overcharging in biological systems: reversal of electrophoretic mobility of aqueous polyaspartate by multivalent cations.


PMID 22681091

Abstract

Charge reversal as an extreme case of charge compensation is directly observed by capillary electrophoresis for a negatively charged peptide in aqueous solutions of trivalent cations. Atomistic and coarse-grained simulations provide molecular interpretation of this effect showing that it is largely of electrostatic origin with a minor contribution of chemical specificity of the salt ions.