EMAIL THIS PAGE TO A FRIEND

The Journal of organic chemistry

Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: synthesis of cyclic amines with a tertiary fluorine at C3.


PMID 22686336

Abstract

As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifluoride (DAST) to produce cyclic β-fluoro amines was studied as well as the enantioselectivity of the process.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

235253
(Diethylamino)sulfur trifluoride, 95%
C4H10F3NS