Anesteziologiia i reanimatologiia

[Anesthesia during trachea intubation in newborns].

PMID 22702155


Evaluation of the effectiveness and safety of analgesics use before planned tracheal intubation in newborns. The study was carried out in 3 groups of full-term newborns: a "control" group(n=19, intravenous atracurium and midazolam before intubation), a "fentanyl" group (n=22, intravenous fentanyl 3mkg/kg together with muscle relaxant and benzodiazepines), a "sevoflurane" group (n=15, intubation under sevoflurane inhalation). On 5 stages were measured HR, BP and SpO2. Skin conductivity was estimated with the monitor MED-STORM Innovation. After tracheal intubation in the control group noted a statistically significant increase in HR (6.5%), and increase in BP (by 7.2%). Also the number of skin conductivity waves increased to 0.13 Hz, which evidenced about the pain stress. In groups "fentanyl" and "sevoflurane" the reaction of HR and skin conductance was absent, and BP decreased, especially in "sevoflurane" group. A lesser number of intubation failures was revealed in the control group and a group of "fentanil", where muscle relaxants were used. Use of analgesics and muscle relaxants before planet tracheal intubation in full-term newborns creates favorable conditions for manipulation.