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Molecular diversity

A novel and efficient one-pot four-component tandem approach for the synthesis of pyran derivatives.


PMID 22729829

Abstract

A series of new pyran derivatives are efficiently synthesized in a one-pot four-component tandem reaction via Suzuki coupling followed by a three-component reaction from readily available 4-bromobenzaldehyde, activated methylene compounds, and carbonyl compounds. Single crystal X-ray structure of the synthesized product is presented. The versatility and efficiency of the proposed methodology has been demonstrated in the synthesis of novel heterocyclic molecules.