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Chemical communications (Cambridge, England)

Development of reversible fluorescence probes based on redox oxoammonium cation for hypobromous acid detection in living cells.


PMID 22735154

Abstract

We describe the synthesis, properties, and application of two reversible fluorescent probes, mCy-TemOH and Cy-TemOH, for HOBr sensing and imaging in live cells. The two probes contain a hydroxylamine functional group for the monitoring of HOBr oxidation/ascorbic acid reduction events. Confocal fluorescence microscopy has established the HOBr detection in live-cells.