EMAIL THIS PAGE TO A FRIEND

European journal of medicinal chemistry

Synthesis and selective anticancer activity of steroidal glycoconjugates.


PMID 22770605

Abstract

The synthesis of glucosamine derivatives of the steroidal sapogenins diosgenin and hecogenin using the N-phthaloyl protected trichloroacetimidate of d-glucosamine as donor and TMSOTf as promoter is reported. The corresponding glycoconjugates were transformed into their acetamido derivatives and the hydrochloride salt (from diosgenin) and tested against HeLa, CaSki, and ViBo cervicouterine cancer cells. These compounds showed low cytotoxicity values on tumor cells and human lymphocytes, indicating that the main cell death process is presumably not necrosis. Significantly, the antiproliferative activity of these compounds on tumor cells did not affect the proliferative potential of peripheral blood lymphocytes.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D1634
Diosgenin, ≥93%
C27H42O3