EMAIL THIS PAGE TO A FRIEND

Oral surgery, oral medicine, oral pathology and oral radiology

Diffuse sclerosing osteomyelitis of the mandible successfully treated with pamidronate: a long-term follow-up report.


PMID 22771405

Abstract

Diffuse sclerosing osteomyelitis of the mandible (DSOM) is an uncommon chronic inflammatory disease of bone that is refractory to conventional treatments, such as antibiotics, nonsteroidal anti-inflammatory drugs, and decortication. We report a case of chronic DSOM of 15 years' duration in a 61-year-old woman that was successfully treated with a single infusion of pamidronate. Persistent, intractable pain resolved 3 days after infusion. Intense accumulation on (99m)Tc scintigraphy decreased 2 months after infusion, and almost disappeared after 3 years. Panoramic radiography demonstrated a clear decrease in pathologic changes, close to that of normal bone architecture, which has not been reported in DSOM treated with bisphosphonates.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

P2371
Pamidronate disodium salt hydrate, ≥95% (NMR), solid
C3H9NO7P2Na2 · xH2O