World journal of gastroenterology

Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism.

PMID 22783053


To introduce a bioimpedance gastric motility measurement method based on an electrical-mechanical composite concept and a preliminary clinical application. A noninvasive gastric motility measurement method combining electrogastrogram (EGG) and impedance gastric motility (IGM) test was used. Preliminary clinical application studies of patients with functional dyspepsia (FD) and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients (mean age 40.9 ± 9.7 years) and 40 healthy volunteers (mean age 30.9 ± 7.9 years) were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients (mean age 50.5 ± 13.0 years) and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after treatment. There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency (PNF) 70.8 ± 25.5 in healthy subjects and 28.3 ± 16.9 in FD patients, P < 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not improved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups (PNF 70.4 ± 25.5 for healthy subjects and 36.1 ± 21.8 for gastritis patients, P < 0.05). The EGG rhythm of the gastritis patients returned to normal (frequency instability coefficient 2.22 ± 0.43 before treatment and 1.77 ± 0.19 one wk after treatment, P < 0.05) after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tendency toward improvement but had not reached statistical significance. The electrical-mechanical composite measurement method showed an attractive clinical application prospect in gastric motility research and evaluation.

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