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Bulletin of experimental biology and medicine

Involvement of P2Y receptors in myocardial contractile activity of rats during postnatal ontogeny.


PMID 22803161

Abstract

We studied the effect of uridine 5'-triphosphate in concentrations of 10(-10)-10(-6) M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5'-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21- and 100-day-old rat pups, exogenous uridine 5'-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditions of P2Y(4) purinoceptor blockade with reagent blue-2. These data indicate that the effect of UTP on the myocardium is realized via P2Y(4) purinoceptors.