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Chemical communications (Cambridge, England)

Membrane protein distribution in composite polymer-lipid thin films.


PMID 22836593

Abstract

We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid drives the protein to a fluid phase, mechanically more similar to a cellular bilayer.