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Rapid communications in mass spectrometry : RCM

Performance and geometry optimization of the ceramic-based rectilinear ion traps.


PMID 22847707

Abstract

The rectilinear ion trap (RIT), as a simplified linear ion trap, has shown great potential in the field of portable mass spectrometers for its simple structure and easy manufacture. In this study, the new ceramic-based rectilinear ion trap (cRIT) was constructed, and the performance and geometry optimization of a series of cRITs were examined. Gold-plated zirconia ceramic electrodes were used to build the cRITs. A home-built electrospray ionization mass spectrometry (ESI-MS) platform was used to test the properties of the cRITs. The protonated ions of arginine (m/z 175) and reserpine (m/z 609) were produced in the experiments by ESI. A series of cRITs with different geometries were constructed, and the overall mechanical accuracy of all parts and the cRIT assembly is within ~10 µm. The mass resolution, the first stability diagram and the tandem mass (MS/MS) analysis capability were tested. For a 6 mm × 5 mm cRIT, the mass resolution was higher than 1800 at m/z 609 when the scan speed was 2190 Th/s. A MS/MS capability with a ca. 94.8% CID efficiency on the cRIT 6 × 5 was obtained. The ceramic-based rectilinear ion trap (cRIT) can be a qualified linear ion trap mass analyzer with high ion storage capability, excellent mass resolution, and high tandem mass analysis efficiency. It can be easily manufactured and operated, and has great potential in ion trap mass spectrometry.