EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.


PMID 22863202

Abstract

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

123129
2-Aminothiazole, 97%
C3H4N2S