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Chemical communications (Cambridge, England)

Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging.


PMID 22914432

Abstract

A cytidine 5'-monophosphate (CMP)-sialic acid analogue carrying a fluorescent reporter group, an inhibitor of sialyltransferase, was synthesised in order to investigate glycan synthesis events in cells. The compound was found to be a substrate of a CMP-sialic acid transporter, and specific Golgi vesicles were visualised in the cells.