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Journal of Asian natural products research

Synthesis and antitumor activity evaluation of new asiatic acid derivatives.


PMID 22924623

Abstract

Twelve novel asiatic acid (AA) derivatives were designed and synthesized. Their structures were confirmed using NMR, MS, and IR spectra. Their in vitro cytotoxicities on various cancer cell lines (HeLa, HepG2, BGC-823, and SKOV3) were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Most of the derivatives were found to have stronger cell growth inhibitory activity than AA. Among them, compounds 5-8 and 11 with substituted amide group at C-28 exhibited more potent cytotoxicity than AA, Gefitinib, and etoposide (positive control).

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546712
Asiatic acid, 97%
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A2612
Asiatic acid, ≥98% (HPLC), from Centella asiatica
C30H48O5