EMAIL THIS PAGE TO A FRIEND

Chinese medical journal

A meta-analytic review of ERCC1/MDR1 polymorphism and chemosensitivity to platinum in patients with advanced non-small cell lung cancer.


PMID 22932088

Abstract

Platinum-based regimens are used as standard first-line chemotherapy in non-small cell lung cancer (NSCLC) patients. To study if pharmacogenetic approach may allow a tailored selection of platinum chemotherapy for advanced NSCLC, we performed a meta-analysis to compare chemosensitivity to platinum with different ERCC1 C118T/ MDR1 C3435T single-nucleotide polymorphism (SNP). Relevant studies were identified by searching the PubMed, Embase, Cochrane, OVID, Springer, EBSCO and CNKI databases. Inclusion criteria were patients with advanced NSCLC who received platinum-based chemotherapy, an evaluated polymorphism of ERCC/MDR1 and overall response rate. We excluded duplicate publications, letters and review articles. The RevMan 4.2 and STATA 11 package were used to do comprehensive quantitative assessment. A total of 11 studies were included in this meta-analysis. For studies evaluating ERCC1 C118T, test for heterogeneity was done (χ(2) = 13.41, P = 0.1), and the odds ratio (OR) for the wild-type C/C genotype versus the heterozygous C/T and T/T genotypes was 1.50 (95% CI 1.09 - 2.06, P = 0.01). In four studies evaluating MDR1 polymorphism, test for heterogeneity was also done (χ(2) = 3.22, P = 0.36), and the OR for the wild-type C/C genotype versus the heterozygous C/T and T/T genotypes was 2.30 (95% CI 1.44 - 3.68, P = 0.0005). The results indicated that platinum-based chemotherapy sensitivity was significantly associated with polymorphism of ERCC1 C118T and MDR1 C3435T SNP. In further perspective studies, the ERCC1/MDR1 SNPs might serve as simple and less invasive biomarkers for personalized chemotherapy with platinum-based anticancer drugs.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

373214
Platinum, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis
Pt
373222
Platinum, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.99% trace metals basis
Pt
373230
Platinum, evaporation slug, diam. × L 0.3 cm × 0.6 cm, 99.99% trace metals basis
Pt
349372
Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis
Pt
267260
Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis
Pt
305189
Platinum, foil, thickness 0.5 mm, 99.9% trace metals basis
Pt
349321
Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis
Pt
327425
Platinum, foil, thickness 0.25 mm, 99.9% trace metals basis
Pt
349348
Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis
Pt
327433
Platinum, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis
Pt
267252
Platinum, foil, thickness 0.1 mm, 99.99% trace metals basis
Pt
349380
Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
Pt
349356
Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis
Pt
303798
Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis
Pt
349364
Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis
Pt
267244
Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis
Pt
298107
Platinum, gauze, 52 mesh, 99.9% trace metals basis
Pt
298093
Platinum, gauze, 100 mesh, 99.9% trace metals basis
Pt
685453
Platinum, nanopowder, <50 nm particle size (TEM)
Pt
204048
Platinum, powder (coarse), 99.99% trace metals basis
Pt
204013
Platinum, powder, 99.995% trace metals basis
Pt
327476
Platinum, powder, ≤10 μm, 99.9% trace metals basis
Pt
327484
Platinum, shot, ≤3 mm, ≥99.9% trace metals basis
Pt
267155
Platinum, sponge, ≥99.9% trace metals basis
Pt
444685
Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
Pt
349399
Platinum, wire, diam. 1.5 mm, ≥99.9% trace metals basis
Pt
267236
Platinum, wire, diam. 1.0 mm, 99.99% trace metals basis
Pt
327492
Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis
Pt
267201
Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis
Pt
267228
Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis
Pt