EMAIL THIS PAGE TO A FRIEND

Organic letters

Pentanidium-catalyzed enantioselective α-hydroxylation of oxindoles using molecular oxygen.


PMID 22946651

Abstract

Pentanidium-catalyzed α-hydroxylation of 3-substituted-2-oxindoles using molecular oxygen has been developed with good yields and enantioselectivities. This reaction does not require an additional reductant such as triethyl phosphite, which was typically added to reduce the peroxide intermediate. The reaction was demonstrated to consist of two-steps: an enantioselective formation of hydroperoxide oxindole and a kinetic resolution of the hydroperoxide oxindole via reduction with enolates generated from the oxindoles.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

O9808
2-Oxindole, 97%
C8H7NO
T61204
Triethyl phosphite, 98%
C6H15O3P