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Organic letters

Regioselective catalytic hydroboration of propargylic species using Cu(I)-NHC complexes.


PMID 22946740

Abstract

The catalytic regioselective hydroboration of propargylic alcohols and ethers was investigated using NHC-CuCl. We observe that different NHC-CuCl complexes catalyze hydroborations of propargylic substrates with opposite regioselectivity. A 6-NHC-CuCl complex provides α-selectivity whereas β-selectivity is achieved using a 5-NHC-CuCl complex. The reaction tolerates a wide range of functional groups.

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P50803
Propargyl alcohol, 99%
C3H4O