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Chembiochem : a European journal of chemical biology

Mapping the mechanism of the resorcinol ring formation catalyzed by ArsB, a type III polyketide synthase from Azotobacter vinelandii.


PMID 22961888

Abstract

Who's first? Aldol cyclization occurs before hydrolysis in the resorcinol ring formation catalyzed by the type III polyketide synthase, ArsB. Synthetic C(20)-TKA was not converted to alkylresorcinol by ArsB, but rather inhibited the enzyme activity, thus indicating that C(20)-TKA is not an intermediate in ArsB-catalyzed alkylresorcinol formation.

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