The Journal of laryngology and otology

Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.

PMID 22963824


To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma. Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival. The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma. Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.