Environmental toxicology and pharmacology

Effects of paraoxon on serum biochemical parameters and oxidative stress induction in various tissues of Wistar and Norway rats.

PMID 23021855


This study investigates the effects of different doses of paroxon (POX), an active metabolite of the organophosphate pesticide parathion, on some serum biochemical parameters and induction of oxidative stress in various tissues of female Wistar and Norway rats. The rats were intraperitoneally treated with 0.3, 0.7, 1 and 1.5 mg/kg of POX. The parameters were evaluated after 24h. The results showed that the decreased glutathione level and catalase, glutathione-S-transferase and lactate dehydrogenase activities in tissues of Wistar rat were higher than Norway rat at higher doses of POX. At these concentrations, POX increased superoxide dismutase activity, malondialdehyde level and some serum biochemical indices. In conclusion, POX induces the production of free radicals and oxidative stress in a dose-dependent manner. Induction of oxidative stress in POX-treated rats is in the order of brain > liver > heart > kidney>spleen. Wistar rat is found to be more sensitive to the toxicity of POX compared to Norway rat.