EMAIL THIS PAGE TO A FRIEND

Angewandte Chemie (International ed. in English)

Heterologous expression and manipulation of three tetracycline biosynthetic pathways.


PMID 23024027

Abstract

A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).