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Chemical communications (Cambridge, England)

Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.


PMID 23073186

Abstract

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.