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Natural product communications

Naturally occurring limonene to cinnamyl-type gamma-butyrolactone substituted aldol condensation derivatives as antioxidant compounds.


PMID 23074886

Abstract

A method has been developed for the synthesis of gamma-butyrolactone substituted cinnamyl type Aldol condensation products under milder proline and triethylamine basic conditions. The antioxidant activity of all the synthesized compounds was assessed using three different assays. The cinnamyl type derivatives of gamma-butyrolactone bearing an -OH group in the benzene ring exhibited excellent antioxidant activity.