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Chemical communications (Cambridge, England)

Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery.


PMID 23108313

Abstract

The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.