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Angewandte Chemie (International ed. in English)

Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions.


PMID 23125029

Abstract

Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.