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Chembiochem : a European journal of chemical biology

Comparison of splicing factor 3b inhibitors in human cells.


PMID 23172726

Abstract

Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.