EMAIL THIS PAGE TO A FRIEND

Fitoterapia

Optimization of the selective preparation of 20(R)-ginsenoside Rg3 catalyzed by d, l-tartaric acid using response surface methodology.


PMID 23219978

Abstract

The optimization of the selective preparation of 20(R)-ginsenoside Rg3 converting protopanaxadiol type saponins (PPD saponins) by the commercially available d, l-tartaric acid was carried out using response surface methodology (RSM) based on a three-factor and six-level central composite design. The optimal 20(R)-ginsenoside Rg3 de% was predicted to be 94.52% in the combination of the factors (d, l-tartaric acid concentration 1.19mol/L, temperature 107.9°C and time 2.79h) through the canonical analysis with maximum responses. Under the optimum reaction conditions, the actual 20(R)-ginsenoside Rg3 de% was 96.49%. 20(R)-ginsenoside Rg3 (1) and 20(S)-ginsenoside Rg3 (2) were separated and identified by (1)H-NMR and (13)C-NMR. Therefore, the RSM was effective to optimize the preparation of 20(R)-ginsenoside Rg3 by converting PPD saponins using d, l-tartaric acid.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

T206
D-(−)-Tartaric acid, ReagentPlus®, 99%
C4H6O6
483796
D-(−)-Tartaric acid, 99%
C4H6O6
95320
D-(−)-Tartaric acid, puriss., unnatural form, ≥99.0% (T)
C4H6O6
03918
DL-Tartaric acid, anhydrous, for ion chromatography, ≥99.5% (T)
C4H6O6
T400
DL-Tartaric acid, ReagentPlus®, 99%
C4H6O6
W304401
DL-Tartaric acid, ≥99%
C4H6O6
50433
DL-Tartaric acid concentrate, 0.1 M HOOC(CHOH)2COOH (0.2N), eluent concentrate for IC
C4H6O6
64139
Ginsenoside Rg3, analytical standard
C42H72O13
SML0184
Ginsenoside Rg3, ≥98% (HPLC)
C42H72O13
W304409
L-(+)-Tartaric acid, ≥99.7%, FCC, FG
C4H6O6
T109
L-(+)-Tartaric acid, ≥99.5%
C4H6O6
T1807
L-(+)-Tartaric acid, BioXtra
C4H6O6
33801
L-(+)-Tartaric acid, puriss. p.a., reag. ISO, reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance)
C4H6O6
41447
L-(+)-Tartaric acid, certified reference material, TraceCERT®
C4H6O6
27504
L-(+)-Tartaric acid, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E334, 99.7-100.5% (calc. to the dried substance), grit
C4H6O6
27506
L-(+)-Tartaric acid, puriss., meets analytical specification of Ph. Eur., NF, 99.7-100.5% (calc. to the dried substance), powder
C4H6O6
95318
L-(+)-Tartaric acid, tested according to Ph.Eur.
C4H6O6
798665
L-(+)-Tartaric acid, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.5%
C4H6O6