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Applied and environmental microbiology

Lucilia sericata chymotrypsin disrupts protein adhesin-mediated staphylococcal biofilm formation.


PMID 23220967

Abstract

Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin derived from maggot excretions/secretions disrupts protein-dependent bacterial biofilm formation mechanisms.