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Acta poloniae pharmaceutica

Synthesis of galactothiophosphoesters of uridine and preliminary tests to evaluate their activity against selected glycosyltransferases.


PMID 23285687

Abstract

Glycoconjugates (8-13) were obtained in condensation reaction of selectively protected thiophosphoesters of uridine with 2,3,4.6-tetra-O-acetyl-1-thio-beta-D-galactose. In sequence of reactions: selective protection of esculine, glycosylation reaction and deprotecion beta-D-galactopiranoside-(1-4)-esculine (20) was obtained as a model of the product reaction catalyzed by GTs. Prepared glycococnjugates (8-13) were checked using TLC methods in terms of inhibition of bovine milk beta-1,4-galactosyltransferase.