EMAIL THIS PAGE TO A FRIEND

Journal of cosmetic science

Protection against UVB-induced oxidative stress in human skin cells and skin models by methionine sulfoxide reductase A.


PMID 23286868

Abstract

Environmental trauma to human skin can lead to oxidative damage of proteins and affect their activity and structure. When methionine becomes oxidized to its sulfoxide form, methionine sulfoxide reductase A (MSRA) reduces it back to methionine. We report here the increase in MSRA in normal human epidermal keratinocytes (NHEK) after ultraviolet B (UVB) radiation, as well as the reduction in hydrogen peroxide levels in NHEK pre-treated with MSRA after exposure. Further, when NHEK were pre-treated with a non-cytotoxic pentapeptide containing methionine sulfoxide (metSO), MSRA expression increased by 18.2%. Additionally, when the media of skin models were supplemented with the metSO pentapeptide and then exposed to UVB, a 31.1% reduction in sunburn cells was evident. We conclude that the presence of MSRA or an externally applied peptide reduces oxidative damage in NHEK and skin models and that MSRA contributes to the protection of proteins against UVB-induced damage in skin.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

64430
DL-Methionine sulfoxide, ≥99.0% (NT)
C5H11NO3S
M1126
L-Methionine sulfoxide
C5H11NO3S