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European journal of medicinal chemistry

Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.


PMID 23287057

Abstract

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.