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A mild and efficient one-pot synthesis of β-amino carbonyl compounds via Mannich reaction under ambient temperature condition.


PMID 23288546

Abstract

We have developed an efficient protocol for the synthesis of β-amino carbonyl compounds using phenylboronic acid as effective and eco-friendly catalyst via one-pot three-component Mannich reaction. Excellent yields, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method, which makes it a useful protocol for the synthesis of β-amino carbonyl compounds.

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78181
Phenylboronic acid, purum, ≥97.0% (HPLC)
C6H7BO2