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Journal of bioscience and bioengineering

Oxidation of aromatic N-heterocyclic compounds to N-oxides by Verticilliumxa0sp.xa0GF39 cells.


PMID 23290448

Abstract

Verticillium sp. GF39, catalyzing the oxidation of 1-methylisoquinoline to 1-methylisoquinoline N-oxide, was found to be the highest N-oxide producer. Under the optimized reaction conditions, the whole cells of Verticillium sp. GF39 formed 5xa0mM 1-methylisoquinoline N-oxide from 1-methylisoquinoline with a molar conversion yield of 100% after a 10-h incubation at 20°C. The whole cells also acted on pyridine, 2-methylpyridine, quinoline and isoquinoline and formed the corresponding N-oxides.

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264938
1-Methylisoquinoline, 97%
C10H9N