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Chemical communications (Cambridge, England)

Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins.


PMID 23296043

Abstract

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.