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Preparative biochemistry & biotechnology

One-pot synthesis of 2,4,5-trisubstituted imidazoles using [BPy]H2PO4, an efficient and recyclable catalyst.


PMID 23302106

Abstract

[BPy]H(2)PO(4) was easily prepared and used as an efficient and recyclable catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions in good to excellent yields. Solvent-free conditions, simple experimental and workup procedures, and the use of a nontoxic, recyclable catalyst of an environmentally benign nature are remarkable features of the procedure.