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Organic letters

Highly enantioselective catalytic phenylation of ketones with a constrained geometry titanium catalyst.


PMID 14507193

Abstract

[reaction: see text] The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.