EMAIL THIS PAGE TO A FRIEND

Macromolecular bioscience

Mimicking native extracellular matrix with phytic acid-crosslinked protein nanofibers for cardiac tissue engineering.


PMID 23335565

Abstract

A functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

593648
Phytic acid solution, 50 % (w/w) in H2O
C6H18O24P6