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Ukrains'kyi biokhimichnyi zhurnal (1999 )

[Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia].


PMID 23342639

Abstract

Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.

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