Environmental toxicology and pharmacology

The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism.

PMID 23376177


Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors are indicated as a possible cause of congenital hypothyroidism. We investigated the associations between endocrine disruptors and the occurrence of congenital hypothyroidism and passage of target compounds from the mother. The levels of phthalates (DEHP, MEHP, DBP, MBP and PA), alkylphenols (n-NP and t-OP), bisphenol, and isoflavones (equol, daidzein and genistein) were determined by gas chromatography-mass spectrometry (GC-MS) in infants. t-OP and PA concentrations in the patient group were significantly higher than in normal infants. Genistein concentrations in normal infants were significantly higher than in patients. We compared the plasma levels of target compounds in infants with their mothers. There was no correlation with the passage of endocrine disruptors and isoflavones from the mothers, except for t-OP, which was weakly correlated between mother and infant.