EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Novel imidazophenoxazine-4-sulfonamides: their synthesis and evaluation as potential inhibitors of PDE4.


PMID 23415088

Abstract

A number of novel imidazophenoxazine-4-sulfonamides have been designed as potential inhibitors of PDE4. All these compounds were readily prepared via an elegant multi-step method involving the initial construction of 1-nitro-10H-phenoxazine ring and then fused imidazole ring as key steps. Some of these compounds showed promising PDE4B and D inhibition when tested in vitro and good interactions with these proteins in silico. Three of these compounds showed dose dependent inhibition of PDE4B with IC50 value of 3.31 ± 0.62, 1.23 ± 0.18 and 0.53 ± 0.18 μM.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

263893
Phenoxazine, ≥99%, purified by sublimation
C12H9NO
P14858
Phenoxazine, 97%
C12H9NO