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Bioorganic & medicinal chemistry

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.


PMID 23434136

Abstract

A total of eight new analogs of pactamycin were prepared and tested alongside pactamycin and three of its natural congeners for antibacterial, anticancer, and antiprotozoal activities. The present study highlights the effects of changing the urea and aniline groups especially with regard to anticancer and antiprotozoal activities.