EMAIL THIS PAGE TO A FRIEND

Critical reviews in toxicology

Considerations for the development of health-based surface dust cleanup criteria for beryllium.


PMID 23445217

Abstract

The exposure-response patterns with beryllium sensitization (BeS), chronic beryllium disease (CBD) and lung cancer are influenced by a number of biological and physicochemical factors. Recent studies have suggested dermal exposure as a pathway for BeS. In light of the current non-health-based DOE Beryllium Rule surface criteria, the feasibility of deriving a human health-based surface dust cleanup criteria (SDCC) for beryllium was assessed based on toxicology and health risk factors via all potential routes of exposure. Beryllium-specific and general exposure factors were evaluated, including (1) beryllium physicochemical characteristics, bioavailability and influence on disease prevalence, and (2) chemical dissipation, resuspension and transfer. SDCC for non-cancer (SDCC) and cancer (SDCC) endpoints were derived from a combination of modern methods applied for occupational, residential and building reentry surface dust criteria. The most conservative SDCC estimates were derived for dermal exposure (5-379 μg/100 cm for 0.1-1% damaged skin and 17-3337 μg/100 cm for intact skin), whereas the SDCC for inhalation exposure ranged from 51 to 485 μg/100 cm. Considering this analysis, the lowest DOE surface criterion of 0.2 μg/100 cm is conservative for minimizing exposure and potential risks associated with beryllium-contaminated surfaces released for non-beryllium industrial or public sector use. Although methodological challenges exist with sampling and analysis procedures, data variability and interpretation of surface dust information in relation to anthropogenic and natural background concentrations, this evaluation should provide useful guidance with regard to cleanup of manufacturing equipment or remediation of property for transfer to the general public or non-beryllium industrial facilities.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

GF60949840
Beryllium, wire reel, 0.1m, diameter 0.85mm, annealed and clean, 99%
Be
GF12366660
Beryllium, rod, 100mm, diameter 7.0mm, 99%
Be
GF41430787
Beryllium, wire reel, 0.05m, diameter 0.85mm, annealed and clean, 99%
Be
GF53985370
Beryllium, wire reel, 0.1m, diameter 0.75mm, annealed and clean, 99%
Be
GF46045627
Beryllium, wire reel, 0.2m, diameter 0.75mm, annealed and clean, 99%
Be
GF95797692
Beryllium, wire reel, 0.5m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF09275823
Beryllium, wire reel, 0.1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF73403142
Beryllium, wire reel, 0.1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF58877948
Beryllium, wire reel, 0.1m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF45831236
Beryllium, wire reel, 0.1m, diameter 0.5mm, annealed and clean, 99%
Be
GF96781214
Beryllium, wire reel, 0.1m, diameter 0.6mm, annealed and clean, 99%
Be
GF59478586
Beryllium, wire reel, 0.2m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF75393388
Beryllium, wire reel, 0.2m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF59743738
Beryllium, wire reel, 0.2m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF29665086
Beryllium, wire reel, 0.2m, diameter 0.5mm, annealed and clean, 99%
Be
GF98865129
Beryllium, wire reel, 0.2m, diameter 0.6mm, annealed and clean, 99%
Be
GF79324959
Beryllium, wire reel, 0.2m, diameter 0.85mm, annealed and clean, 99%
Be
GF67966385
Beryllium, wire reel, 0.3m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF11051558
Beryllium, wire reel, 0.5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF34823224
Beryllium, wire reel, 0.5m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF24172703
Beryllium, wire reel, 0.5m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF81444764
Beryllium, wire reel, 1m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF52902840
Beryllium, wire reel, 1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF21588565
Beryllium, wire reel, 1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF80595793
Beryllium, wire reel, 5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF02814702
Beryllium, mesh, 5x5mm, nominal aperture 0.13mm, thickness 0.025mm, wire diameter 0.1mm, 100 wires/inch, open area 50%, electro-formed mesh
Be
GF06987224
Beryllium, wire reel, 0.05m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF21271025
Beryllium, wire reel, 0.05m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF28341840
Beryllium, wire reel, 0.05m, diameter 0.5mm, annealed and clean, 99%
Be
GF65661363
Beryllium, wire reel, 0.05m, diameter 0.6mm, annealed and clean, 99%
Be