EMAIL THIS PAGE TO A FRIEND

British journal of haematology

Oncogenic properties of sphingosine kinases in haematological malignancies.


PMID 23521541

Abstract

The sphingosine kinases (SphKs) have relatively recently been implicated in contributing to malignant cellular processes with particular interest in the oncogenic properties of SPHK1. Whilst SPHK1 has received considerable attention as a putative oncoprotein, SPHK2 has been much more difficult to study, with often conflicting data surrounding its role in cancer. Initial studies focused on non-haemopoietic malignancies, however a growing body of literature on the role of sphingolipid metabolism in haemopoietic malignancies is now emerging. This review provides an overview of the current state of knowledge of the SphKs and the bioactive lipid sphingosine 1-phosphate (S1P), the product of the reaction they catalyse. It then reviews the current literature regarding the roles of S1P and the SphKs in haemopoietic malignancies and discusses the compounds currently available that modulate sphingolipid metabolism and their potential and shortcomings as therapeutic agents for the treatment of haematological malignancies.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

S9666
Sphingosine 1-phosphate, ≥95%, powder
C18H38NO5P
73914
Sphingosine 1-phosphate, ≥98.0% (TLC)
C18H38NO5P