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The Journal of antibiotics

Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.


PMID 2358406

Abstract

6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.

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E1310000 Erythromycin B, European Pharmacopoeia (EP) Reference Standard
C37H67NO12