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Antimicrobial agents and chemotherapy

Pharmacodynamics modeling to optimize dosage regimens of sulbactam.


PMID 23650160

Abstract

The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodynamic targets. The results indicated that a regimen consisting of a 4-h infusion of 3 g of sulbactam every 8 h would be an alternative treatment option for less-susceptible pathogens.

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Y0000529 Sulbactam sodium, European Pharmacopoeia (EP) Reference Standard