EMAIL THIS PAGE TO A FRIEND

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Sphingosine 1-phosphate in renal diseases.


PMID 23736205

Abstract

Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

S9666
Sphingosine 1-phosphate, ≥95%, powder
C18H38NO5P
73914
Sphingosine 1-phosphate, ≥98.0% (TLC)
C18H38NO5P